J Thromb Haemost. PubMed MacNeil JR, Su JR, Broder KB, et al. 2021;21(4):4502. Lancet Infect Dis. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH. Curr Cardiol Rep. 2014;16(6):110. https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions.html. Some symptoms are similar to those caused by chronic fatigue syndrome and other chronic illnesses that develop after infections. The Food and Drug Administration announced a new warning for the Johnson & Johnson coronavirus vaccine on Monday, saying the shot has been linked to a serious but rare side effect called. It is noteworthy that rare and scattered reports have been published on the side effects of Sinopharm and other inactivated virus-based vaccines (Table 1). Syncope and seizures following human papillomavirus vaccination: a retrospective case series. The CDC noted that the two mRNA vaccines, from Pfizer and Moderna, are preferred over the Johnson & Johnson vaccine, which remains available for those who prefer it and for use in certain circumstances. In connection with brain disorders, the possible mechanism is the entry of inflammatory mediators secreted by peripheral blood cells into the brain and the destruction of myelin and axonal degeneration. 241(d); 5 U.S.C. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. 2021. https://doi.org/10.1136/jnnp-2021-327027. Cureus. Despite concerns over Covid vaccines, most side effects occur with hours or weeks of having a jab. 2021;90(4):62739. The Pfizer-BioNTech Covid-19 vaccine is associated with an increased risk of myocarditis, an inflammation of the heart muscle, a large new study from Israel confirms. The most important and common complicationsare cerebrovasculardisorders including cerebral venous sinus thrombosis, transient ischemic attack, intracerebral hemorrhage, ischemic stroke, and demyelinatingdisorders including transverse myelitis, first manifestation of MS, and neuromyelitis optica. 2022. https://doi.org/10.7759/cureus.21376. invader and attacks it with immune cells, the weapons it would use against any virus or . Amyotrophic neuralgia secondary to Vaxzevria (AstraZeneca) COVID-19 vaccine. Acta Neurol Belg. Khan E, Shrestha AK, Colantonio MA, Liberio RN, Sriwastava S. Acute transverse myelitis following SARS-CoV-2 vaccination: a case report and review of literature. i had been worried about it beforehand but not to the point where i had an attack. Venous sinus thrombosis is associated with excessive coagulation. According to published information on the side effects of other adenovirus vaccines, it is essential to properly evaluate the efficacy of the Sputnik vaccine and publish relevant data to decide on its side effects. Accessed May 6, 2022. Sputnik-V reactogenicity and immunogenicity in the blood and mucosa: a prospective cohort study. By comparison, 60 reports of syncope after receipt of influenza vaccination were identified during July 1, 2019June 30, 2020 (0.05 episodes of syncope per 100,000 doses of influenza vaccine administered). Google Scholar. Recommendations for observation after COVID-19 vaccine administration are available at https://www.cdc.gov/vaccines/covid-19/info-by-product/clinical-considerations.html. Ish S, Ish P. Facial nerve palsy after COVID-19 vaccinationA rare association or a coincidence. COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. 2021. https://doi.org/10.1007/s10072-021-05662-9. Comput Struct Biotechnol J. 2021;208: 106887. Fever or chills. 2021;12:879. Five mass vaccination sites reported 64 anxiety-related events, including 17 events of syncope (fainting) after receipt of Janssen COVID-19 vaccine. The Lancet. 2021;19:250817. If you had COVID-19 before being vaccinated, the first injection may cause more noticeable side effects than for people who have not had the coronavirus. Tidsskrift for Den norske legeforening. PubMed Central Keir G, Maria NI, Kirsch CF. 2021;24: e01143. Reporting rates were calculated using the approximate number of doses of each vaccine administered during the respective analysis periods. Descriptive analyses of VAERS data were stratified by vaccine type, sex, and age group. Like a fish yanked from a pond, I flopped onto a hard plastic chair . The most commonly reported symptoms of post-COVID-19 syndrome include: Keep in mind that it can be hard to tell if you are having symptoms due to COVID-19 or another cause, such as a preexisting medical condition. These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. Brain Hemorrhages. This conversion might result in character translation or format errors in the HTML version. To compare the occurrence of these events with those reported after receipt of other vaccines, reports of syncopal events after influenza vaccine administered in the 201920 influenza season were also reviewed. Up to 10 percent of people who have COVID experience side effects" such as difficulty thinking, pain, tiredness, loss of taste and depression. For some people, the second [] loss of smell. VST is the most severe disorder that should be diagnosed and controlled immediately. Ramdeny S, Lang A, Al-Izzi S, Hung A, Anwar I, Kumar P. Management of a patient with a rare congenital limb malformation syndrome after SARS-CoV-2 vaccine-induced thrombosis and thrombocytopenia (VITT). statement and Vaccines. Google Scholar, who.int. J Am Acad Dermatol. COV2. Springer Nature. https://covid19.who.int/mapFilter=deaths. AskMayoExpert. 2021;25(5):3023. Fitzsimmons W, Nance CS. Patient tips: Healthcare provider appointments for post-COVID conditions. Its helpful to understand side effects before you get a COVID-19 vaccine. The most common side effects are a sore arm and sometimes fever, chills, tiredness and headaches for a day or two, according to the CDC. Institute of Medicine of the National Academies. Brain Commun. "Please," I pleaded, "can I lie on the floor?". I truly believe this is a side effect of the vaccine. When I stood, the panic erupted horns blaring. Getting the COVID-19 vaccine offers you ample protection against the virus but can also cause a few non-serious side effects such as fatigue, soreness at the injection site, nausea, chills, or a . Muscle aches. The symptoms usually peak in about ten minutes and then begin to subside. muscle or joint aches. World Health Organization. Front Immunol. Understand the possible symptoms and risk factors for post-COVID-19 syndrome. . Cookies used to track the effectiveness of CDC public health campaigns through clickthrough data. Pulmonary embolism, transient ischaemic attack and thrombocytopenia after the Johnson & Johnson COVID-19 vaccine. Use of trade names and commercial sources is for identification only and does not imply endorsement by the U.S. Department of S Vaccine. Al-Mashdali AF, Ata YM, Sadik N. Post-COVID-19 vaccine acute hyperactive encephalopathy with dramatic response to methylprednisolone: a case report. IDCases. World J Clin Cases. Post SARS-CoV-2 vaccination Guillain-Barre syndrome in 19 patients. QJM: An Int J Med. Garg RK, Paliwal VK. The vast majority of myocarditis or pericarditis cases are mild and resolve quickly. 2021;69: 102803. CDC and FDA do not provide individual medical treatment, advice, or diagnosis. As of November 2022, 630.3 million people have been diagnosed with COVID-19 and 6.58 million deaths worldwide, according to WHO figures [2]. 2021. https://doi.org/10.4045/tidsskr.21.0312. Finsterer J. Anxiety-related adverse events following immunization (AEFI): a systematic review of published clusters of illness. Repajic M, Lai XL, Xu P, Liu A. Bells Palsy after second dose of Pfizer COVID-19 vaccination in a patient with history of recurrent Bells palsy. Fan H-T, Lin Y-Y, Chiang W-F, Lin C-Y, Chen M-H, Wu K-A, Chan J-S, Kao Y-H, Shyu H-Y, Hsiao P-J. Following these events, as expected, peripheral blood cells and albumin enter the brain and disrupt the osmotic balance [10]. MMWR Morb Mortal Wkly Rep 2021;70:6516. Privacy The CDC says people with allergies to certain foods, insects, latex and other common allergens can safely receive the COVID-19 vaccine. Herein, we have provided a comprehensive review of documents reporting neurological side effects of COVID-19 vaccines in international databases from 2020 to 2022 and discussed neurological disorders possibly caused by vaccination. Tahir N, Koorapati G, Prasad S, Jeelani HM, Sherchan R, Shrestha J, Shayuk M. SARS-CoV-2 vaccination-induced transverse myelitis. The reversible tinnitus and cochleopathy followed first-dose AstraZeneca COVID-19 vaccination. 2021;67: 102540. 2021. https://doi.org/10.1136/bmj.n1786. Google Scholar. panic attacks after vaccine. pain at the site of the injection. Due to the activity of the immune system, after the injection of COVID-19 vaccines, especially adenovirus-based type, thrombocytopenia, cerebral venous sinus thrombosis, ischemic stroke and intracerebral hemorrhage, have also been reported [27]. Ramasamy MN, Minassian AM, Ewer KJ, Flaxman AL, Folegatti PM, Owens DR, Voysey M, Aley PK, Angus B, Babbage G. Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial. 2021;202:1823. The mechanism of induction of this disorder is the development of autoimmunity by molecular mimicry. Neurological complications of COVID-19: Guillain-Barre syndrome following Pfizer COVID-19 vaccine. Syncope after vaccinationUnited States, January 2005July 2007. Headache. McGonagle D, De Marco G, Bridgewood C. Mechanisms of immunothrombosis in vaccine-induced thrombotic thrombocytopenia (VITT) compared to natural SARS-CoV-2 infection. Some patients and survivors say the experience has triggered panic attacks and debilitating anxiety for the first time. Sixteen (27%) reports indicated that the patient had received more than one vaccine immediately before the syncopal episode. Cookies policy. Loza AMM, Holroyd KB, Johnson SA, Pilgrim DM, Amato AA. 2021;12:20837. On the other hand, severe neurological complications included Bell's palsy, GuillainBarre syndrome (GBS), stroke, seizures, anaphylaxis, and demyelinating syndromes such as transverse myelitis and acute encephalomyelitis [10]. Vaccine 2018;36:299305. Martin-Villares C, Vazquez-Feito A, Gonzalez-Gimeno M, de la Nogal-Fernandez B. Bells palsy following a single dose of mRNA SARS-CoV-2 vaccine: a case report. Ercoli T, Lutzoni L, Orofino G, Muroni A, Defazio G. Functional neurological disorder after COVID-19 vaccination. * Each VAERS report might be assigned more than one MedDRA preferred term. Abraham G, Bhalala OG, de Bakker PI, Ripatti S, Inouye M. Towards a molecular systems model of coronary artery disease. Rodrguez-Jimnez P, Chicharro P, Cabrera L-M, Segu M, Morales-Caballero , Llamas-Velasco M, Snchez-Prez J. Varicella-zoster virus reactivation after SARS-CoV-2 BNT162b2 mRNA vaccination: report of 5 cases. Most side effects stop within 48 hours. Venous sinus thrombosis and cerebral hemorrhage are more common in women between the ages of 30 and 50 than in men (Table 2) [8]. Dyer O. Covid-19: Regulators warn that rare Guillain-Barr cases may link to J&J and AstraZeneca vaccines. 2021;358: 577661. Among people age 65 and older, 1 in 4 has at least one medical condition that might be due to COVID-19. 2020;396(10267):197993. However, anyone who gets COVID-19 can have long-term effects, including people with no symptoms or mild illness with COVID-19. 2021;64(1):E1. Clin Med (Northfield Il). 2014;13(3):21524. CDC interviewed staff members from the five mass COVID-19 vaccination sites that reported anxiety-related adverse event clusters after receipt of Janssen COVID-19 vaccine, focusing on site capacity and layout, vaccination processes, timeline of reported events, and clinical follow-up. By comparison, after influenza vaccination, the reporting rate of syncope was 0.05 episodes per 100,000 doses. Because the results of the phase 4 studies are the proper criteria for how the vaccine works in the real world [5]. According to data from the CDC, VAERS, and EMA databases, the short-term outcome of COVID-19 vaccination is promising, but in the medium and long term, especially with some vaccines, side effects have been reported that are worrisome. Br J Haematol. But the side effect. Sharifian-Dorche M, Bahmanyar M, Sharifian-Dorche A, Mohammadi P, Nomovi M, Mowla A. Vaccine-induced immune thrombotic thrombocytopenia and cerebral venous sinus thrombosis post COVID-19 vaccination; a systematic review. Median patient age was 36 years (range=1877 years). In vaccines containing inactive or protein viruses, virus particles and proteins, as antigens, trigger the immune system [4]. 2021;111:21926. How well do face masks protect against COVID-19? Clin Neurol Neurosurg. The Lancet. New! In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. J Neuroimmunol. Saeed BQ, Al-Shahrabi R, Alhaj SS, Alkokhardi ZM, Adrees AO. https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/post-covid-appointment/index.html. https://www.cdc.gov/mis/index.html. Wait -- could I have. Part of People who had severe illness with COVID-19 might experience organ damage affecting the heart, kidneys, skin and brain. QJM: An Int J Med. Int Med Case Rep J. Article I would encourage you to give us a call on the Beyond Blue Support Service; we're available 24/7 by phone on 1300 22 4636. 2021. https://doi.org/10.1007/s12024-021-00440-7. Zhang Y, Zeng G, Pan H, Li C, Hu Y, Chu K, Han W, Chen Z, Tang R, Yin W. Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 1859 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. J Neurol. All vaccines could cause some degree of reaction, and the same is true for COVID-19 vaccines. Ideggyogyaszati Szemle. MMWR and Morbidity and Mortality Weekly Report are service marks of the U.S. Department of Health and Human Services. Clin Park Relat Disord. COVID-19: Who's at higher risk of serious symptoms? 2021;70(9):9313. RH: carried out the searched publications, classified the documents, and wrote the manuscript draft. Acute transverse myelitis after inactivated COVID-19 vaccine. Following the COVID-19 virus epidemic, extensive, coordinated international research has led to the rapid development of effective vaccines. 1; 2; First Prev 2 of 2 Go to page. Typical side effects may include swelling or pain at the point of injection, tiredness, fever or headache, as well as muscular. Gbel CH, Heinze A, Karstedt S, Morscheck M, Tashiro L, Cirkel A, Hamid Q, Halwani R, Temsah M-H, Ziemann M. Clinical characteristics of headache after vaccination against COVID-19 (coronavirus SARS-CoV-2) with the BNT162b2 mRNA vaccine: a multicentre observational cohort study. My symptoms started on a Monday and lasted through the weekend- brain fog, dizziness, feeling faint, vision shaky. 2021;9(5):435. These include anaphylaxis, a severe reaction . Finsterer J, Scorza FA, Scorza CA. These symptoms do not mean you are sick. As a follow-up to these interviews, CDC reviewed VAERS reports received during March 2April 22, 2021, for adverse events associated with receipt of Janssen COVID-19 vaccine doses administered during March 2April 12. Exacerbating Guillain-Barr Syndrome Eight Days after vector-based COVID-19 vaccination. muscle aches. 2021;428: 117607. Panic attacks every time I try to get the Covid vaccine. Accessed May 24, 2022. Int J Med Pharm Case Rep: 20-24. Other types of side effects from the coronavirus vaccines are not unusual. What a timely discovery! These activities were reviewed by CDC and were conducted consistent with applicable federal law and CDC policy.. Typical side effects include pain at the injection site, fever, fatigue, headache, muscle pain, chills and diarrhoea. part 46, 21 C.F.R. Eur J Med Res 28, 102 (2023). Feelings of anxiety can range from mild to severe. COV2. That is the most troubling unknown for me." 2021;14(7): e243829. #BestPractices. J Eur Acad Dermatol Venereol. State and local health departments that participated in this investigation. 2022;50(1): e80. 2021;269(3):112132. Contact your healthcare provider. Complications usually appear within one day to 1month after injection and are usually acute, transient, and self-limiting, but in severe cases lead to hospitalization and intensive care [8]. Most events resolved within 15 minutes with supportive care. Thirteen (20%) patients were transported to an emergency department for further medical evaluation; among these, all five for whom follow-up information was available were released from medical care on the same day. Neuroimmunology Reports. The problem occurs more often in adolescents (teens) and young adults, and in males. Vaccine providers should be aware of anxiety-related events after vaccination and observe all COVID-19 vaccine recipients for any adverse reactions for at least 15 minutes after vaccine administration. Pfizer's new RSV vaccine for older adults may trigger the potentially deadly Guillain-Barre syndrome, the Food and Drug Administration has warned.. RT @FearDept: New study shows artificial sweetener "linked to blood clotting, stroke, heart attack and death" -- the four most frequently reported severe side effects of our COVID vaccines. Keywords used for this search included COVID-19, SARS-CoV-2, vaccination, side effects, complications, vascular thrombosis, thrombocytopenia, myelitis, demyelination, and all kind of mRNA vaccines, Adenovirus vaccine, Pfizer, AstraZeneca, Johnson & Johnson, Moderna, Sinovac, Sinopharm, Sputnik, and Covaxin. Clark RT, Johnson L, Billotti J, Foulds G, Ketels T, Heard K, Hynes EC. 42(45):36675. The Advisory Committee on Immunization Practices reaffirmed its recommendation for the use of Janssen COVID-19 vaccine on April 23, 2021; a warning for rare clotting events, primarily in women aged 1849 years is now included by FDA in the EUA and provider and patient information sheets (8). Washington, DC: The National Academies Press; 2012. Jain E, Pandav K, Regmi P, Michel G, Altshuler I. Facial diplegia: a rare, atypical variant of Guillain-Barr syndrome and Ad26. Vaccine 2015;33:4398405. PubMed Approximately one half of reports to VAERS of syncope after Janssen COVID-19 vaccination were for persons in the youngest age group (1829 years) recommended for vaccination. Focus on anything other than the needle stick: a spot on the floor, the positive effects of getting a COVID-19 vaccine (soon you can hug your family! Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. Fever. The most commonly reported side effects were: Fever Headache Fatigue (tiredness) Pain at the injection site Helpful tips to relieve side effects Adults To relieve pain or swelling on the arm where you got the shot: Apply a clean, cool, wet washcloth over the area. Their concern regarding vaccines' efficacy and side effects. First, VAERS is a passive surveillance reporting system and subject to underreporting (1). The knock-on effects coronavirus is having on people's mental health is also a likely cause for the rise. Ann Med Surg. Six persons who received diphenhydramine or epinephrine at the vaccination visit were excluded because these events might have represented allergic reactions; none was classified as anaphylaxis. In a short-term sense, you may find it useful to talk to somebody who can provide you non-judgemental support, advice, and immediate assistance. Because the Janssen COVID-19 vaccine is administered as a single dose, this vaccine might be a more attractive option for persons who have needle aversion. PubMed Central Google Scholar. But as I sat for the required 15 minutes of observation time, a wave of something engulfed my body. But some people even those who had mild versions of the disease might have symptoms that last a long time afterward. Article Hum Vaccin Immunother. "It's really hard whether to say this is something that happened independently or is it complications from the vaccine until you can look at large populations of people and look at their side. J Neurol. Herpes zoster is a disease that occurs as a result of the reactivation of the varicella-zoster virus (VZV) after receiving the COVID-19 vaccine. Allen CM, Ramsamy S, Tarr AW, Tighe PJ, Irving WL, Tanasescu R, Evans JR. Guillain-Barr syndrome variant occurring after SARS-CoV-2 vaccination. MMWR Morb Mortal Wkly Rep 2021;70:685688. Centers for Disease Control and Prevention. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Symptoms of long COVID. Shimabukuro TT, Nguyen M, Martin D, DeStefano F. Safety monitoring in the Vaccine Adverse Event Reporting System (VAERS). Because COVID-19 vaccines are urgently approved, meaning they do not complete the standard clinical trials, the adverse effects of each vaccine should be closely monitored. Bull-Otterson L, et al. QJM: An Int J Med. Vaccine viral antigens activate platelets or indirectly cause blood to clot by activating complement pathways and increasing thrombin production. Approximately one quarter of the syncopal and other anxiety-related events after receipt of Janssen COVID-19 vaccine described in this report occurred in persons who reported a history of similar events after vaccination. Althoughvaccines are now considered the best way to achieve collective safety and control mortality, due to the critical situation, these vaccines have been issued the emergency use licenses andsome of theirpotentialsubsequence side effects have been overlooked. pain and soreness at injection site. Malik B, Kalantary A, Rikabi K, Kunadi A. According to the vaccine study literature, adverse effects have always been part of the mass vaccination strategy, but ultimately the desired effects of the vaccination are more significant. A panel of experts at the virtual American Academy of Allergy, Asthma and Immunology Annual Meeting highlighted current evidence on allergic reactions to available COVID-19 vaccines and how to. People with severe symptoms of COVID-19 often need to be treated in a hospital intensive care unit. Blauenfeldt RA, Kristensen SR, Ernstsen SL, Kristensen CCH, Simonsen CZ, Hvas AM. Clin Neurol Neurosurg. 2022;269(1):478. headache. Among the 60 reports of syncope after influenza vaccine, 15 (25%) indicated that the patient had a history of syncope or needle aversion. VAERS reports of syncopal events occurring after receipt of any influenza vaccine administered to persons aged 18 years during the 201920 influenza season (i.e., July 1, 2019June 30, 2020) served as a comparison, because influenza vaccine is similarly administered as a single dose and is available to all U.S. adults. Ismail II, Salama S. A systematic review of cases of CNS demyelination following COVID-19 vaccination. Views equals page views plus PDF downloads, US case reports of cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccinationMarch 2 to April 21, 2021external icon. What are the implications for public health practice? We take your privacy seriously. Researchers have used the body's own immune cells to develop a nano-vaccine against Covid-19, according to a new study conducted in mice. 2021. https://doi.org/10.7759/cureus.13426. Research, Review, and Case Report articles related to adverse effects of COVID-19 vaccination from 2020 to February 2022 were searched and reviewed in Google Scholar, PubMed, and NCBI databases. BMJ Case Reports CP. painful, swollen lymph nodes in the arm where the vaccine was injected. The anxiety-related events described here were reported before reports of thrombosis with thrombocytopenia syndrome (7). Liu BD, Ugolini C, Jha P. Two cases of post-Moderna COVID-19 vaccine encephalopathy associated with nonconvulsive status epilepticus. 2021;397(10269):99111. Most side effects were mild to moderate. Corresponding author: Anne M. Hause, voe5@cdc.gov. DOI: http://dx.doi.org/10.15585/mmwr.mm7018e3external icon. Cureus. 31 On the contrary, people in poor and developing countries, including health workers, have not received full COVID-19 immunization. 2021. https://doi.org/10.1111/jdv.17555. Other tips to combat anxiety over the COVID vaccine: Check your imagination: COVID vaccine anxiety is often fueled by "what-if's"imagined scenarios of the many ways events can head south. Guillain-Barr syndrome in the placebo and active arms of a COVID-19 vaccine clinical trial: temporal associations do not imply causality. 3501 et seq. Transverse myelitis has been observed after injection of mRNA and adenovirus-based vaccines, and it is noteworthy that mRNA-based vaccines can cause exacerbation or early manifestation of MS and neuromyelitis optica. This virus is known to cause widespread lung infection and hypoxia [1]. Vaccine reactivity has been linked to a temporary increase in inflammatory cytokines that act on blood vessels, muscles, and other tissues. Masks are required inside all of our care facilities, COVID-19 testing locations on Maryland.gov, Coronavirus Symptoms: Frequently Asked Questions. COV2.S vaccination. n R, truncov D. Status epilepticus as a complication after COVID-19 mRNA-1273 vaccine: a case report. 2021;121: 102662. Cao L, Ren L. Acute disseminated encephalomyelitis after severe acute respiratory syndrome coronavirus 2 vaccination: a case report. Panic attacks are reported to be increasing during COVID-19, as people are increasingly worried about their health. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. * VAERS reports are classified as serious if any of the following are reported: hospitalization, prolongation of hospitalization, life-threatening illness, permanent disability, congenital anomaly or birth defect, or death. texas syndicate rank structure, jacksonville high school football coaching staff, negative effects of idolizing celebrities,